My patient who is 5 months pregnant and suffering from debilitating morning sickness with vomiting and nausea throughout the day, asked me "If you were pregnant, would you use cannabis?".
This is a question I get quite often.
My answer is that it all depends.
The benefits must outweigh the risks.
Every so often another scary piece about cannabis damaging the brains of babies and children crops up, just as it did in this piece in the New York Times: “Pregnant Women Turn to Marijuana, Perhaps Harming Infants”. The story pointed to several preliminary studies indicating that pregnant women who use cannabis risk having babies that are underweight and possibly cognitively impaired.
Dr. Stacey Kerr, physician and medical advisor to Hawaiian Ethos, a medical cannabis dispensary in Hawaii discussed this important topic with Medical Cannabis Mentor.
In utero development is not to be taken lightly, so it’s crucial to parse myth from fact. Of course, a pregnant woman should exercise caution when using any medication or substance that might affect the health of her baby as her blood is comingled with that of her fetus. But cannabinoids don’t function like other molecules and at this point, there’s a small, but growing amount of evidence that they might actually might further a baby’s development, or at least do no harm. It’s not the commonly expressed point of view, but it’s crucial to remember that most of the science in the US has been carried out by the National Institute of Drug Abuse, which has a mission to only investigate the harmful effects of the plant while ignoring the benefits. Twenty years ago, science assured us that the concept of medical marijuana was a joke. Yes, science, too, can change its collective mind.
Here’s what we know
The most prevalent cannabinoids found in cannabis, THC, and CBD, are bioidentical to two chemicals produced by the human brain, anandamide and 2AG. The next question is: Why does the brain produce these chemicals? What is their function?
The answer, in part, was offered by the late Dr. Ester Fride, an Israeli neuroscientist who was investigating the ways cannabinoids influence a newborn’s development. Her science showed that without a functioning endocannabinoid system newborn rats failed to suckle or begin maternal bonding. They died much sooner than babies with functioning endocannabinoid systems. Fride concluded that endocannabinoids are essential to a baby’s ability to thrive.
Equally compelling is the work Dr. Melanie Dreher, the Dean of Nursing at Rush Medical Center in Chicago. In the early 1990s Dreher traveled to Jamaica to investigate a group of rural and impoverished Rastafarian women and their infants. These “Roots Daughters” smoke ganja as a daily health ritual; they rely on it to maintain appetite, rest and allay nausea during pregnancy. They also serve a mild ganja tea to their families as a health tonic -- when you’re poor it’s less expensive to forestall illness than to treat it once it hits.
Dreher followed 30 Roots Daughters and their babies for five years until the children entered school. She found that infants whose moms smoked ganja socialized more quickly made eye contact more quickly, and were easier to engage than the babies of non-smokers. There were no developmental differences between the groups. In fact, on tests for verbal ability, motor, perceptual and quantitative skills, memory, and mood, the kids of smokers scored higher.
“Given what everyone else was finding at the same time, we thought [our findings] were pretty darned interesting and a little counterintuitive,” Dreher told me.
Though her findings were unprecedented they were published in 1994 to resounding silence. In the wake of that silence, Dreher applied to NIDA for additional funding to return to Jamaica to follow the same children at age 10 but her request was denied. Instead, NIDA continued to commission more studies from which researchers concluded that exposure to (extraordinary quantities of) cannabis in the womb might harm the brain, lower IQ, and damage “executive function.” Different variations on these dire warnings are still being trumpeted today.
Life Not Matching Research
Women throughout the world have been using cannabis as a natural medicine for centuries with no apparent harm, so for an alternate interpretation of the findings cited in the Times, I spoke to Dr. Stacy Kerr, a family physician and cannabis educator in Santa Rosa, CA. Dr. Kerr is one of the rare physicians who openly discusses her use of cannabis (probably because she works in a state that has had an operational medical marijuana program since 1996). “I grew up in the 1960s and we used cannabis when we were pregnant, and we were pregnant a lot,” Kerr, a mother of two, now in their 40s, tells me. “I delivered kids who were exposed in utero and watched them through childhood and into adulthood and I’m not seeing the results of these studies play out. I’m a physician and I want to believe these studies, but real life outcomes weren’t matching the research predictions.”
With the assistance of other researchers and a statistician, she examined the research most frequently quoted and found some notable discrepancies with the ways the samples were put together and the extrapolations of the findings.
In the studies of babies being born at lower weights, she discovered that all the women surveyed were asked if they had used any psychoactive substances (not specifically cannabis) and were also all from lower socio-economic backgrounds at a public hospital. Both factors could have influenced the results. She also points out, crucially, that there was no difference in the Apgar score, the measures the 5 key indicators of a baby’s health just after birth.
The other frequently quoted study by claims that kids of cannabis using moms do less well in life and are slower in school. But this research, according to Kerr, was skewed by factors other than prenatal exposure.
Are cannabinoids the same as other molecules?
The final claim is that prenatal exposure to THC somehow miswires the brain and impairs cognitive development. Indeed, endocannabinoids are active in the fetal brain. They help neurons grow in the correct direction and yes, using cannabis does add additional cannabinoids into to the equation, perhaps displacing those that occur naturally in the body. But there is no research to date showing that displacing those naturally occurring endocannabinoids is definitively problematic.
In fact, there is another study hinting that additional cannabinoids seem to somehow protect neural functioning. Those researchers looked a complex neural process called “global motion perception” that is damaged in kids with abnormal brain developments, such as autism or fetal alcohol syndrome. (Kids with impaired GMP are characterized as “seeing the trees but not the forest.” They see individual details in their field of vision but not the entire frame.) In addition, exposure to both cannabis and alcohol seemed to cancel each other out.
Kerr’s conclusion: “It’s not ‘drink alcohol and use cannabis and your baby will be just fine,’ but it is interesting that exposure to THC in brain improved this indicator of neural development.”
A question of intent
Clearly, the mystery of cannabinoids and pregnancy is yet to be solved. In the meantime, I asked Kerr if she were pregnant again if she’d use cannabis? To my surprise, she hesitated before answering.
“I hesitated because pregnant women today are going crazy -- there’s always another article on more that we can’t do, so for me, it comes back to intent and how you use cannabis as a medicine. If I am nauseated or in pain, or if I have a two-year-old who’s going crazy and making me so irritable that I’m yelling at the kids and my husband and if taking a puff relaxes me and makes me nicer then, sure, I’d use it.
“That said, there is also such a thing as cannabis abuse disorder so if a patient is using too much and the kids aren’t being fed or the house isn’t getting cleaned I’d think about it differently and advise them to stop.
“But making women afraid that something drastic is going to happen if they take a vapor hit or a puff on a joint based on the current science isn’t beneficial.”
The take-home message:
A pregnant woman should be careful when using any medication or substance that might affect the health of her baby because any time you give a medicine, the primary concern is how much of that medication gets passed through the placenta.
When you are pregnant, you should be abstaining from as many extraneous chemicals and toxins as possible. Our internal endocannabinoid system plays a critical role in modulating female and male reproductive systems and there is a whole galaxy of endocannabinoid receptors in the uterus, the ovaries, and the fallopian tube.
There are not enough long term studies related to CBD use and pregnancy or any human trials yet to make an evidence-based decision.
However, if your symptoms cannot be treated in any other way and you are endangering your baby by not getting enough nutrition and the benefits outweigh the risks, then CBD and cannabinoid medication can be an option.
As always, please consult your doctor before integrating medical cannabis as it can also interact with your current medications and supplements.
12/21/2022 01:26:58 am
Thiss was great to read
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